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Forty-five people lost their lives after the bus they were traveling in crashed as they came from Botswana to attend an Easter church service in South Africa, local media reported.
One eight-year-old child is reported to have survived.
The bus crashed through a barrier and plunged into a ravine before catching fire in Limpopo province in the north-east of the country, local media are saying.
Transport Minister Sindisiwe Chikunga went to scene of the accident.
“I am sending my heartfelt condolences to the families affected by the tragic bus crash… Our thoughts and prayers are with you during this difficult time. We continue to urge responsible driving at all times with heightened alertness as more people are on our roads this Easter weekend,” she said.
