In a statement published on its website, the United Nations Environment Programme (UNEP) says leaded petrol has been eradicated from the world.
The agency described the end of the use of leaded petrol as a “huge milestone”.
The fuel has contaminated the atmosphere, drinking water and crops for nearly a century.
The UN says its abolition will save 1.2 million premature deaths every year, largely by reducing heart disease and cancer.
The leaded petrol also damages the developing brains of children.
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By the 1980s, most rich countries had banned the use of leaded petrol but it was only last month that Algeria, the last country to use the fuel, ran out of supplies, reports the BBC.